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Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining
08:04

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Published on: February 8, 2019

The treatment of gonorrhoea--beta lactamase producers

V S Rajan

    Annals of the Academy of Medicine, Singapore
    |January 1, 1983
    PubMed

    Insights

    High rates of penicillin-resistant gonorrhea (PPNG) necessitate replacing penicillin with effective antibiotics like spectinomycin and cephalosporins. Future treatment guidelines must consider impacts on non-PPNG strains and potential syphilis resurgence.

    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Public Health

    Background:

    • Penicillin resistance in Neisseria gonorrhoeae (PPNG) is a growing global concern.
    • The routine use of procaine penicillin for gonorrhea treatment is becoming increasingly ineffective due to high PPNG endemicity.

    Purpose of the Study:

    • To evaluate alternative first-line antibiotic treatments for gonorrhea.
    • To assess the implications of shifting from penicillin to alternative antibiotics for gonorrhea management.

    Main Methods:

    • Review of current epidemiological data on PPNG prevalence.
    • Analysis of antibiotic efficacy against Neisseria gonorrhoeae, including PPNG and non-PPNG strains.
    • Consideration of potential public health consequences of treatment guideline changes.

    Main Results:

    • Aminoglycosides, spectinomycin, and second/third-generation cephalosporins demonstrate high efficacy against gonorrhea.
    • Shifting treatment away from penicillin may impact non-PPNG strains and could lead to chromosomal resistance.
    • Discontinuation of penicillin may result in an increase in early syphilis cases.

    Conclusions:

    • Antibiotics such as spectinomycin and cephalosporins should be considered for first-line gonorrhea treatment due to PPNG.
    • Future treatment recommendations must address potential resistance development and the risk of syphilis resurgence.
    • Further research into synergistic antibiotic combinations, including beta-lactam/beta-lactamase inhibitor combinations, is warranted.

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