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T-cell prolymphocytic leukemia with a suppressor phenotype.

A T Planas, K W Zamkoff, B J Poiesz

    Annals of Clinical and Laboratory Science
    |May 1, 1983
    PubMed
    Summary

    This study identifies a rare case of prolymphocytic leukemia in a 50-year-old man, classifying the neoplastic cells as mature suppressor T lymphocytes based on immunophenotyping. The findings contribute to understanding T-cell prolymphocytic leukemia subtypes.

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    Blood·2001

    Area of Science:

    • Hematology
    • Immunology
    • Oncology

    Background:

    • Prolymphocytic leukemia (PLL) is an aggressive lymphoid malignancy.
    • Distinguishing between T-cell and B-cell PLL is crucial for prognosis and treatment.
    • This study investigates a specific case to clarify cell lineage and characteristics.

    Observation:

    • A 50-year-old male patient presented with prolymphocytic leukemia.
    • Neoplastic cells were analyzed using light and electron microscopy.
    • Cytochemical stains showed focal positivity for acid phosphatase and alpha naphthyl acetate esterase.

    Findings:

    • Immunophenotyping revealed neoplastic cells formed rosettes with sheep erythrocytes.
    • Cells reacted with Leu-1 and Leu-2a but not Leu-3a antisera.

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  • Terminal deoxynucleotidyl transferase (TdT) activity was absent, indicating mature T lymphocytes.

    • Implications:

    • The neoplastic cells were identified as phenotypically mature suppressor T lymphocytes.
    • This case expands the understanding of T-cell prolymphocytic leukemia.
    • Comparison with B-cell PLL highlights distinct clinico-pathological and immunological features.