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Related Experiment Videos

Auditory brain-stem responses in infants with Down's syndrome.

R C Folsom, J E Widen, W R Wilson

    Archives of Otolaryngology (Chicago, Ill. : 1960)
    |September 1, 1983
    PubMed
    Summary

    Infants with Down syndrome show distinct auditory brain-stem response patterns compared to typically developing infants. These differences in wave V latency suggest unique auditory pathway development and necessitate specific normative data for this population.

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    Area of Science:

    • Neuroscience
    • Developmental Pediatrics
    • Audiology

    Background:

    • Auditory brain-stem responses (ABRs) are crucial for assessing auditory pathway function in infants.
    • Down syndrome is associated with various developmental differences, including potential auditory processing variations.

    Purpose of the Study:

    • To investigate age- and intensity-dependent changes in auditory brain-stem responses (ABRs) in infants with Down syndrome.
    • To compare ABR latency patterns between infants with Down syndrome and typically developing infants.

    Main Methods:

    • Auditory brain-stem responses to click stimuli were recorded from 38 infants with Down syndrome and 35 typically developing infants at 3, 6, and 12 months of age.
    • Latency of wave V was analyzed across different age points and sound intensities.

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    Main Results:

    • Infants with Down syndrome exhibited significantly different wave V latency compared to controls.
    • Shorter absolute wave V latencies and steeper latency-intensity functions were observed in the Down syndrome group across age and intensity.
    • These differences were particularly notable at 12 months of age.

    Conclusions:

    • Established normative ABR latency-intensity curves for typically developing infants are inadequate for infants with Down syndrome.
    • Cochlear function may differ between infants with Down syndrome and normal infants by 12 months of age.
    • This highlights the need for specialized audiological assessments in infants with Down syndrome.