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Diagnostic strategy in hyperandrogenic syndrome
Hormone Research
|January 1, 1983
Summary
Elevated testosterone and androstenedione levels are common in women with acne and hirsutism. Treatment with cyproterone acetate significantly improved these conditions.
Area of Science:
- Endocrinology
- Dermatology
Background:
- Acne and hirsutism in women are often associated with androgen excess.
- Hormonal imbalances, including elevated testosterone and androstenedione, are implicated in these conditions.
Purpose of the Study:
- To investigate hormonal profiles in women with acne and/or hirsutism.
- To evaluate the efficacy of cyproterone acetate in treating these conditions.
Main Methods:
- Measured plasma testosterone (T), androstenedione (A), FSH, LH, PRL, and urinary 17-CS in 152 women.
- Compared hormonal levels to controls.
- Assessed treatment outcomes with cyproterone acetate.
Main Results:
- Significantly increased mean plasma levels of T, A, LH, PRL, and urinary 17-CS were observed in patients compared to controls.
- Elevated T and/or A were found in 59% of cases.
- Hirsutism improved in 64% and acne in 84% of patients treated with cyproterone acetate.
Conclusions:
- Women with acne and/or hirsutism frequently exhibit elevated androgens and other hormonal abnormalities.
- Cyproterone acetate demonstrates significant efficacy in managing both hirsutism and acne in affected women.