Related Experiment Video

Updated: Jul 25, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Factor VIII-related antigen and procoagulant activity in manic-depressive patients

D O Ho-Yen, D S Kay, R Henderson

    Journal of Affective Disorders
    |August 1, 1983
    PubMed

    Insights

    Manic-depressive patients show altered levels of Factor VIII-related antigen (VIIIR:AG) and procoagulant activity (VIII:C). These levels correlate with hospital admissions and disease onset, suggesting a link between blood clotting factors and bipolar disorder.

    Area of Science:

    • Hematology
    • Psychiatry
    • Clinical Biochemistry

    Background:

    • Manic-depressive illness, also known as bipolar disorder, is a mood disorder characterized by shifts in mood, energy, and activity levels.
    • Factor VIII is a crucial protein in the blood coagulation cascade, essential for hemostasis.
    • Previous research has explored potential links between various physiological factors and psychiatric conditions.

    Purpose of the Study:

    • To investigate the levels of Factor VIII-related antigen (VIIIR:AG) and Factor VIII procoagulant activity (VIII:C) in patients with manic-depressive illness.
    • To determine if these factor levels correlate with clinical parameters such as the number of hospital admissions and age of disease onset.

    Main Methods:

    • Weekly measurements of VIIIR:AG and VIII:C were conducted in 11 hospitalized manic-depressive patients.
    • Statistical analyses were performed to assess correlations between factor levels and clinical data, including hospital admission frequency and age of onset.
    • VIIIR:AG levels in patients were compared to those in a control group.

    Main Results:

    • Significant correlations were found between VIII:C and the number of hospital admissions (P < 0.02).
    • Significant correlations were also observed between VIIIR:AG and the number of hospital admissions (P < 0.05).
    • Patients exhibited a wider range of VIIIR:AG results compared to controls (P < 0.01), and the age of disease onset, not patient age, correlated with VIIIR:AG (P < 0.02).

    Conclusions:

    • Factor VIII parameters (VIIIR:AG and VIII:C) may be altered in individuals with manic-depressive illness.
    • These alterations show a relationship with the long-term course of the illness, indicated by hospital admission frequency.
    • The findings suggest a potential biological link between the coagulation system and the pathophysiology of bipolar disorder, warranting further investigation.

    More Related Videos

    Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)04:56

    Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

    Published on: August 4, 2023

    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation04:37

    Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

    Published on: May 23, 2025

    Related Concept Videos

    Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

    Anticoagulant Drugs: Low-Molecular-Weight Heparins

    Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
    Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

    Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

    Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
    Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
    Mania and Antimanic Drugs: Overview01:24

    Mania and Antimanic Drugs: Overview

    Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
    Extrinsic and Intrinsic Pathways of Hemostasis01:20

    Extrinsic and Intrinsic Pathways of Hemostasis

    Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
    The Extrinsic Pathway
    The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
    Disorders of Hemostasis01:24

    Disorders of Hemostasis

    Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
    Thromboembolic Disorders
    Two factors primarily cause thromboembolic conditions.
    Bipolar Disorder01:30

    Bipolar Disorder

    Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.