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Esophageal dysfunction in Down's syndrome.

C Hillemeier, P J Buchin, J Gryboski

    Journal of Pediatric Gastroenterology and Nutrition
    |January 1, 1982
    PubMed
    Summary
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    Children with Down syndrome often experience esophageal dysfunction, leading to serious complications like pneumonia and strictures from gastroesophageal reflux. Some may also have abnormal esophageal peristalsis without reflux.

    Area of Science:

    • Pediatric Gastroenterology
    • Down Syndrome Research
    • Esophageal Motility Disorders

    Background:

    • Down syndrome is associated with various health issues, including potential gastrointestinal complications.
    • Esophageal function abnormalities can impact children's health and well-being.

    Observation:

    • Seven children with Down syndrome were evaluated for esophageal function.
    • Three children presented with recurrent pneumonia linked to gastroesophageal reflux.
    • Two of these children, plus one other, had esophageal strictures.

    Findings:

    • Significant esophageal peristalsis abnormalities were observed in two patients without gastroesophageal reflux.
    • Gastroesophageal reflux was identified as a cause of pneumonia and strictures in some patients.

    Related Experiment Videos

  • The study highlights a spectrum of esophageal dysfunction in children with Down syndrome.

    • Implications:

    • Ambulatory children with Down syndrome may be at increased risk for severe gastroesophageal reflux sequelae.
    • Early identification and management of esophageal dysfunction are crucial in this population.
    • Further research into the specific mechanisms of esophageal abnormalities in Down syndrome is warranted.