[Effect of ketanserin on various properties of pentobarbital in rats]

Rats pre-treated with the quinazoline-dione derivative Ketanserin (1,25, 2,5 and 5 mg.kg-1, i.p.) (Janssen Pharmaceutica, Beerse, Belgium) present a more prolonged general anaesthesia and a more pronounced incapacity to stand up when injected with pentobarbital (30 to 120 mg.kg-1, i.p.). Cold shivering linked to Ketanserin is also suppressed.