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Related Experiment Videos

Ultrastructural basis for ciliary motility.

B A Afzelius

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    The complex machinery of cilia and sperm tails, including dynein arms and microtubular doublets, enables movement. Studying ciliary mutants and chemical dissection reveals insights into these structures and related human diseases.

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    Cilia-related diseases.

    The Journal of pathology·2004

    Area of Science:

    • Cell Biology
    • Biophysics
    • Genetics

    Background:

    • The axoneme, the core structure of cilia and sperm tails, is a complex molecular machine responsible for motility.
    • Dynein arms drive microtubule sliding, while nexin links and spokes regulate bending and stability.
    • The ciliary necklace may control cilium activity via calcium ion regulation.

    Purpose of the Study:

    • To explore the intricate components and functions of the ciliary machinery.
    • To understand the mechanisms underlying ciliary movement and its regulation.
    • To investigate the genetic and molecular basis of ciliary dysfunction.

    Main Methods:

    • Chemical dissection of ciliary components.
    • Analysis of ciliary mutants from protists.

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  • Clinical investigation of human patients with ciliary disorders, such as immotile cilia syndrome.

    • Main Results:

    • Identified key roles of dynein arms, nexin links, and spokes in ciliary bending and stability.
    • Demonstrated the influence of the ciliary necklace on cilium activity.
    • Linked ciliary defects in human patients to the immotile cilia syndrome.

    Conclusions:

    • The ciliary axoneme is a sophisticated mechano-chemical apparatus.
    • Ciliary function is essential for processes like mucus clearance and male fertility.
    • Ciliary mutants provide valuable models for studying human diseases.