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Cryptococcal meningitis. An atypical presentation.

P Custer, L A Breen, R M Burde

    Journal of Clinical Neuro-Ophthalmology
    |March 1, 1982
    PubMed
    Summary
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    A young woman developed cryptococcal meningitis, presenting with double vision and neurological deficits. This case is the first to document Horner's syndrome linked to this fungal infection.

    Area of Science:

    • Neurology
    • Infectious Diseases
    • Ophthalmology

    Background:

    • Cryptococcal meningitis is a serious fungal infection primarily affecting immunocompromised individuals.
    • Neurological complications can arise from cryptococcal meningitis, impacting cranial nerves and brain function.

    Observation:

    • A previously healthy 23-year-old female presented with horizontal diplopia.
    • Physical examination revealed bilateral sixth cranial nerve palsies, papilledema, right Horner's syndrome, and right hemiparesis.

    Findings:

    • Cerebrospinal fluid analysis confirmed the presence of Cryptococcus neoformans.
    • This marks the first documented instance of Horner's syndrome occurring in conjunction with cryptococcal meningitis.

    Implications:

    Related Experiment Videos

    • Highlights the potential for atypical neurological presentations in cryptococcal meningitis.
    • Underscores the importance of considering fungal infections in patients with unexplained neurological and ophthalmological signs.
    • Suggests a need for further research into the mechanisms linking cryptococcal meningitis and specific neurological syndromes like Horner's syndrome.