Related Experiment Video
Updated: Aug 31, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
[Amineptine versus imipramine. Double-blind controlled study]
Abstract:
The antidepressant properties of amineptine and imipramine were compared in a double-blind controlled trial involving 38 patients randomized to one or the other treatment. The results were evaluated globally using three scales of psychiatric assessment: Hamilton's depression rating scale, brief psychiatric rating scale (Pichot, Overall and Gorham) and nursing staff observation scale (N.O.S.I.E.). Statistical analysis of the overall score, individual items and grouped items failed to demonstrate any significant difference between the two drugs for the periods considered. Detailed information is provided on the acceptability of both drugs, particularly as regards the cardiovascular system.
Related Concept Videos
Blind Procedures
Drugs Affecting Neurotransmitter Release or Uptake
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Antidepressant Drugs: MAOIs and Other Agents
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...

