Jove
Visualize
Contact Us

Related Experiment Videos

The phenytoin syndrome.

R S Tomsick

    Cutis
    |December 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    The phenytoin syndrome is a severe hypersensitivity reaction to phenytoin, causing fever, rash, and organ damage. Management is challenging due to potential relapses even after discontinuing the drug.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Renaut bodies. Benign disease process mimicking neurotropic tumor infiltration.

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·1996
    Same author

    Local anesthetics.

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·1996
    Same author

    Scaly atrophic lesions both scattered and in linear arrays. Disseminated superficial actinic porokeratosis in a patient with linear porokeratosis.

    Archives of dermatology·1991
    Same author

    Epidermolysis bullosa acquisita antigen, a major cutaneous basement membrane component, is synthesized by human dermal fibroblasts and other cutaneous tissues.

    The Journal of investigative dermatology·1986
    Same author

    Squamous cell carcinoma of the fingers treated with chemosurgery.

    Southern medical journal·1984
    Same author

    Biopsy methods for melanoma.

    Cutis·1983
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Pharmacology
    • Immunology
    • Dermatology

    Background:

    • Phenytoin is an anticonvulsant medication.
    • Hypersensitivity reactions can occur with drug use.
    • The phenytoin syndrome is a specific drug-induced hypersensitivity.

    Observation:

    • Reviewed five cases of the phenytoin syndrome.
    • Characterized by fever, rash, lymphadenopathy, and hepatitis.
    • Associated symptoms include anemia, pharyngitis, diarrhea, and nephritis.

    Findings:

    • Skin eruptions are varied, including morbilliform, follicular, erythroderma, and toxic epidermal necrolysis.
    • The syndrome presents a diagnostic challenge due to its diverse manifestations.
    • Patients may experience relapses even after phenytoin withdrawal.

    Implications:

    • Highlights the importance of recognizing diverse phenytoin hypersensitivity presentations.
    • Emphasizes the need for vigilant monitoring and management strategies.
    • Informs clinical practice regarding potential drug-induced adverse events.