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Related Experiment Videos

Co-operative dynamics in organelles.

H Shimizu, H Haken

    Journal of Theoretical Biology
    |September 21, 1983
    PubMed
    Summary

    Organelles exhibiting spontaneous dynamics, like muscle contraction, are often viewed as organized systems. However, this study reveals they are self-organizing, with molecular elements linked via feedback loops.

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    Area of Science:

    • Biophysics
    • Systems Biology
    • Molecular Biology

    Background:

    • Organelles can exhibit ordered macroscopic dynamics, such as sarcomere shortening in muscle.
    • Traditionally, these are considered organized molecular systems with independent elements.
    • This view may arise from experiments constraining macroscopic dynamics.

    Purpose of the Study:

    • To re-evaluate the nature of organelles exhibiting spontaneous dynamics.
    • To distinguish between organized and self-organizing systems.
    • To identify criteria for recognizing self-organizing systems.

    Main Methods:

    • Application of principles from synergetics.
    • Development of criteria to identify self-organizing systems.
    • Analysis of skeletal muscle actomyosin behavior.

    Main Results:

    • Self-organizing systems require "free" macroscopic dynamics for feedback loops.
    • Constrained dynamics can make self-organizing systems appear organized.
    • Skeletal muscle actomyosin acts as a cooperative element in self-organization.

    Conclusions:

    • Organelles with spontaneous dynamics should be viewed as self-organizing systems.
    • Synergetics provides criteria to identify these systems.
    • Skeletal muscle actomyosin exemplifies self-organization in biological systems.

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