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Correlation of parietal cell structure and function.

J G Forte, T M Forte, J A Black

    Journal of Clinical Gastroenterology
    |January 1, 1983
    PubMed
    Summary
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    Gastric parietal cells expand their apical surface during HCl secretion via membrane recycling. This process involves tubulovesicles fusing with the plasma membrane, facilitated by microfilaments, to enable efficient acid transport.

    Area of Science:

    • Cell Biology
    • Physiology
    • Membrane Transport

    Background:

    • Gastric parietal cells secrete HCl, a process involving significant apical membrane rearrangement.
    • The H+/K+-ATPase is the key proton pump, but its function depends on membrane dynamics and ion availability.

    Purpose of the Study:

    • To investigate the membrane dynamics and transport mechanisms underlying gastric acid secretion.
    • To elucidate the role of tubulovesicles and microfilaments in parietal cell function.

    Main Methods:

    • Cell fractionation of resting and stimulated oxyntic mucosa.
    • Analysis of H+/K+-ATPase activity and localization.
    • Identification of transport systems in different membrane fractions.

    Main Results:

    Related Experiment Videos

    • H+/K+-ATPase is primarily in tubulovesicles in resting cells.
    • Stimulation leads to H+/K+-ATPase redistribution to larger, stimulation-associated vesicles.
    • A KCl cotransport system identified in these vesicles works with the H+-K+-ATPase.

    Conclusions:

    • Membrane recycling via tubulovesicle fusion is crucial for apical surface expansion during HCl secretion.
    • The coordinated action of H+/K+-ATPase and KCl cotransport facilitates net HCl transport in parietal cells.