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[Interstitial pneumopathy in subjects treated with amiodarone]
Presse Medicale (Paris, France : 1983)
|November 26, 1983
Summary
Amiodarone may cause rare lung damage called fibrinogenic interstitial pneumopathy. This drug is linked to 56% of diagnosed cases, suggesting it plays a role in iatrogenic pulmonary fibrosis.
Area of Science:
- Pulmonology
- Pharmacology
- Toxicology
Background:
- Amiodarone is an antiarrhythmic drug.
- Interstitial pneumopathy is a lung disease affecting the tissue around the air sacs.
- Fibrinogenic interstitial pneumopathy is a specific type characterized by fibrin deposition.
Observation:
- Five new cases of interstitial fibrinogenic pneumopathy were reported.
- These add to 17 previously published cases.
- A significant proportion of patients with this condition had taken amiodarone.
Findings:
- A strong association exists between amiodarone use and fibrinogenic interstitial pneumopathy.
- In a study group, 56% of patients with this lung condition had ingested amiodarone.
- Amiodarone is implicated as a significant factor in the development of iatrogenic pulmonary fibroses.
Implications:
- Amiodarone is a potential cause of drug-induced lung fibrosis.
- This condition, though rare, may be underdiagnosed.
- Clinicians should consider amiodarone toxicity in patients presenting with interstitial lung disease.