Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunomodulating activity of p-hydroxyphenyllactic and ascorbic acids].

A V Sergeev

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |March 1, 1984
    PubMed
    Summary

    p-Hydroxyphenyl lactic acid (PHA) inhibits lymphocyte proliferation in colonic cancer patients. Ascorbic acid counteracted this effect, enhancing immune responses in specific contexts.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Migraine attack therapy: from new efficacy criteria to novel therapeutic formulations].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
    Same author

    [TERTp mutation screening using digital droplet PCR of collection of 52 paired DNA samples from blood plasma and tumor tissue in patients with glioblastoma].

    Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko·2025
    Same author

    [Gender aspects of attention deficit hyperactivity disorder].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2025
    Same author

    Optimizing the charge transport in redox-active gels: a computational study.

    Soft matter·2024
    Same author

    Theoretical Study of Microgel Functional Groups' Mobility.

    The journal of physical chemistry. B·2023
    Same author

    [Interaction of DNA Methyltransferase Dnmt3a with Phosphorus Analogs of S-Adenosylmethionine and S-Adenosylhomocysteine].

    Molekuliarnaia biologiia·2023

    Area of Science:

    • Immunology
    • Cell Biology
    • Cancer Research

    Context:

    • Investigating the immunomodulatory effects of p-Hydroxyphenyl lactic acid (PHA) and ascorbic acid.
    • Focusing on lymphocyte proliferation in response to alloantigens and mitogens.
    • Examining responses in colonic cancer patients and in animal models.

    Purpose:

    • To determine the impact of PHA on cell proliferation and immune responses.
    • To assess the modulatory effect of ascorbic acid on PHA-induced changes.
    • To explore PHA's influence on cytotoxic T lymphocyte production and allogeneic mixed lymphocyte culture (MLC).

    Summary:

    • PHA (5 x 10(-5) M) significantly inhibited lymphocyte proliferation in response to alloantigens and suboptimal Con A in colonic cancer patients.
    • Ascorbic acid administration increased lymphocyte proliferation to alloantigens and Con A.
    • PHA did not affect cytotoxic T lymphocyte production in allogeneic mouse spleen MLC but inhibited proliferation in specific mouse models.

    Impact:

    • Highlights PHA's potential immunosuppressive role in certain cancer contexts.
    • Suggests ascorbic acid may restore or enhance immune function compromised by PHA.
    • Provides insights into PHA's differential effects based on lymphocyte source and stimulation conditions.

    Related Experiment Videos