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[Posttransfusion purpura: identification of a new platelet antigen Leka. A case]
Abstract:
A young female patient with Gardner's syndrome developed post-transfusion purpura. Serological studies demonstrated the presence of an antibody directed not against PlA1 but against a new antigen, Leka. This is the first case of post-transfusion purpura not associated with immunization against the PlA1 antigen. The Leka antigen is present in 98% of the French population. Its absence on platelets from patients with thrombasthenia suggests that it is located on the IIb IIIa platelet glycoprotein complex.