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Patch test responses evaluated by cutaneous blood flow measurements.

B Staberg, P Klemp, J Serup

    Archives of Dermatology
    |June 1, 1984
    PubMed
    Summary
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    Laser-Doppler measurements quantitatively assess patch test reactions. This technique differentiates negative and doubtful reactions but cannot distinguish between weak and strong positive results.

    Area of Science:

    • Dermatology
    • Biomedical Engineering

    Background:

    • Standard patch testing relies on visual assessment of skin reactions.
    • Objective, quantitative measures are needed to improve patch test interpretation.

    Purpose of the Study:

    • To evaluate laser-Doppler flowmetry as a quantitative method for assessing cutaneous blood flow in patch test reactions.
    • To compare laser-Doppler measurements with conventional visual grading of patch test results.

    Main Methods:

    • Laser-Doppler flowmetry was used to measure cutaneous blood flow at patch test sites.
    • Blood flow was compared between negative, doubtful, and positive (1+, 2+) reactions.
    • Measurements were compared to standard visual readings.

    Main Results:

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    • Cutaneous blood flow significantly increased in positive patch test reactions compared to basal levels.
    • Doubtful (?+) reactions showed a fivefold increase, while weak (1+) and strong (2+) reactions showed a tenfold increase.
    • No significant difference in blood flow was observed between 1+ and 2+ reactions.

    Conclusions:

    • Laser-Doppler flowmetry offers a quantitative method to distinguish between negative, doubtful, and positive patch test reactions.
    • This technique may aid in standardizing patch test interpretation.
    • Further methods are required to differentiate between weak (1+) and strong (2+) positive reactions.