Cardiac size and function in Paget's disease of bone

Area of Science:

• Cardiology
• Orthopedics
• Medical Imaging

Background:

• Paget's disease of bone is a chronic condition affecting bone remodeling.
• Cardiac involvement in Paget's disease is not fully understood, particularly in relation to disease severity.

Purpose of the Study:

• To assess cardiac size and function non-invasively in patients with Paget's disease.
• To correlate cardiac parameters with the extent of skeletal involvement in Paget's disease.

Main Methods:

• Non-invasive cardiac assessment including clinical criteria, electrocardiography, chest X-ray, systolic time intervals, and echocardiography.
• Comparison between 27 Paget's disease patients (Group I: <15% skeletal involvement; Group II: >15% skeletal involvement) and 20 controls.

Main Results:

• Group II patients showed cardiomegaly, increased left ventricular diastolic dimension, and ventricular hypertrophy compared to controls.
• Extensive skeletal involvement correlated with depressed myocardial contractility and enlarged left ventricular volumes.
• No significant differences in cardiac output were observed between groups.

Conclusions:

• Paget's disease of bone, especially with >15% skeletal involvement, is associated with cardiac enlargement and impaired left ventricular function.
• These findings highlight the importance of cardiac monitoring in patients with severe Paget's disease.