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[Neonatal bacterial infections. Kinetic study of C-reactive protein and orosomucoid]
Insights
Neonatal infection markers, C-reactive protein (CRP) and orosomucoid, rise significantly in infants with materno-fetal infections. Monitoring these proteins aids in assessing treatment effectiveness for neonatal infections.
Area of Science:
- Biochemistry
- Neonatal Medicine
- Immunology
Context:
- Neonatal infections pose significant health risks.
- Materno-fetal and nosocomial infections are common in newborns.
- Biomarkers are crucial for diagnosing and managing neonatal infections.
Purpose:
- To investigate the dynamic changes in serum C-reactive protein (CRP) and orosomucoid concentrations in neonates with different types of infections.
- To evaluate the utility of CRP and orosomucoid as indicators of infection and treatment response in neonates.
Summary:
- Serum CRP and orosomucoid levels were analyzed in 134 neonates with materno-fetal (n=111) or nosocomial (n=23) infections.
- Both proteins were significantly elevated in neonates with materno-fetal infections.
- Elevated levels of CRP and orosomucoid were observed before clinical symptoms in superinfection cases, with orosomucoid changes following CRP.
- Monitoring these protein levels can help assess treatment efficacy and guide treatment withdrawal.
Impact:
- Establishes CRP and orosomucoid as valuable biomarkers for early detection and management of neonatal infections.
- Provides insights into the temporal relationship between CRP and orosomucoid changes during infection.
- Supports the use of these biomarkers for monitoring therapeutic response and optimizing treatment duration in neonates.
Abstract:
Changes in serum concentrations versus time of C reactive protein and orosomucoid were investigated in 134 neonates with either materno-foetal infection (group A, n = 111) or nosocomial infection (group B, n = 23). Both proteins were significantly elevated in group A neonates, with mean +/- S.E.M. values of 0.029 +/- 0,003 g/l for C reactive protein (n = 111) and 0.56 +/- 0.003 g/l for orosomucoid (n = 37). In cases with superinfection serum levels of both proteins rose before clinical symptoms developed. Changes in orosomucoid concentrations occurred a few hours after changes in C reactive protein concentrations. Monitoring C reactive protein and orosomucoid levels, in an excellent means of assessing the effectiveness of treatment and of deciding on its withdrawal when both proteins return to normal values.