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[Antiandrogens and acne].

R Aron-Brunetière, C Dutouquet, G Ventura

Annales De Dermatologie Et De Venereologie

|January 1, 1984

Summary

High-dose cyproterone acetate (Androcur) significantly improved severe acne, including seborrhea, comedones, and eruptions, compared to low-dose treatment. Topical treatments did not alter Androcur

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Area of Science:

Dermatology
Pharmacology

Background:

Severe acne vulgaris affects numerous patients, often necessitating effective therapeutic interventions.
Cyproterone acetate is a known anti-androgen used in acne treatment.

Purpose of the Study:

To compare the efficacy of high-dose versus low-dose cyproterone acetate for severe acne.
To evaluate the impact of topical treatments when used with cyproterone acetate.

Main Methods:

144 patients with severe acne were treated with either low-dose Diane (2 mg/day for 21 days) or high-dose Androcur (50-100 mg/day for 10 days) in an inverse sequential schedule.
Efficacy was assessed based on seborrhea, comedones, and eruptions.
The study also assessed outcomes with and without adjunctive topical treatments (Tretinoin or Benzoyl peroxide).

Main Results:

High-dose Androcur demonstrated a highly significant improvement in seborrhea, comedones, and eruptions compared to low-dose Diane.
The efficacy of Androcur was consistent regardless of whether 50 mg or 100 mg was administered.
Adjunctive topical treatments did not significantly alter the positive outcomes observed with Androcur.

Conclusions:

High-dose cyproterone acetate (Androcur) is a more effective treatment for severe acne vulgaris than low-dose cyproterone acetate (Diane).
Androcur shows significant efficacy in managing seborrhea, comedones, and inflammatory lesions.
The drug is well-tolerated, and its effectiveness is not diminished by concurrent topical therapies.

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