Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multiple sclerosis. Current etiopathogenic concepts].

C Confavreux

    Presse Medicale (Paris, France : 1983)
    |September 15, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Non-metastatic breast cancer patients discontinuing aromatase inhibitor on denosumab: what next?

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
    Same author

    Management of bone metastasis and cancer treatment-induced bone loss during the COVID-19 pandemic: An international perspective and recommendations.

    Journal of bone oncology·2021
    Same author

    Variabilities in µQCT-based FEA of a tumoral bone mice model.

    Journal of biomechanics·2021
    Same author

    [Pharmaceutical interviews for rheumatoid arthritis patients: Perceptions and expectations of community pharmacists].

    Annales pharmaceutiques francaises·2018
    Same author

    Effect of intra-tibial injection on mechanical properties of mouse bone.

    Computer methods in biomechanics and biomedical engineering·2017
    Same author

    A 10-year follow-up of the European multicenter trial of interferon β-1b in secondary-progressive multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2015
    Same journal

    Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Ethical, legal, and regulatory challenges in AI-based healthcare tools.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Decision-making for clinicians.

    Presse medicale (Paris, France : 1983)·2026
    See all related articles

    The exact cause of multiple sclerosis (MS) remains unclear, with current research questioning the significance of genetics and the role of viruses like measles. Autoimmunity in MS may be a consequence, not the cause, of nervous system damage.

    Area of Science:

    • Neuroimmunology
    • Pathogenesis of Demyelinating Diseases

    Background:

    • The pathogenesis of multiple sclerosis (MS) is not fully understood.
    • While genetic susceptibility and exogenous factors are implicated, twin studies suggest a minor genetic contribution.
    • Observed immunological abnormalities in MS lack a coherent explanatory framework.

    Purpose of the Study:

    • To critically evaluate current theories on multiple sclerosis pathogenesis.
    • To explore the potential roles of genetic predisposition, viral infections, and autoimmunity.
    • To address the limitations in understanding the underlying mechanisms of MS.

    Main Methods:

    • Review of existing literature on MS etiology.
    • Analysis of twin studies regarding genetic influence.

    Related Experiment Videos

  • Evaluation of immunological findings, including T-lymphocyte function.
  • Assessment of evidence for viral triggers, specifically measles virus.
  • Consideration of the autoimmune theory and potential target antigens.

    • Main Results:

    • Genetic factors appear to play a minor role in MS development.
    • The hypothesis of suppressor T-lymphocyte failure is considered an oversimplification.
    • Evidence for a viral origin, including measles virus, is inconclusive or likely negative.
    • The target antigen in autoimmune theories remains unidentified.
    • Observed autoimmune signs may be secondary to neural tissue destruction.

    Conclusions:

    • The etiology of multiple sclerosis is complex and multifactorial.
    • Current evidence does not definitively support a primary viral or autoimmune cause.
    • Further research is needed to elucidate the precise mechanisms driving MS pathogenesis.