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Updated: Aug 8, 2026
12:37
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Summary
Musk ambrette causes photosensitivity in men, with some developing persistent reactions. Related nitromusks like moskene and musk xylene may also cause cross-reactions, while musk ambrette alone can cause skin reactions.
Area of Science:
- Dermatology
- Photodermatology
- Toxicology
Background:
- Musk ambrette is a synthetic fragrance ingredient.
- Photosensitivity reactions to fragrances can impact quality of life.
- Previous reports suggest potential photosensitizing properties of musk ambrette.
Observation:
- 19 men with suspected photosensitivity were evaluated.
- 15 men showed photosensitivity to musk ambrette upon photopatch testing.
- 6 patients experienced persistent adverse reactions to sunlight.
Findings:
- Musk ambrette confirmed as a photosensitizer in 19 men.
- Cross-reactions observed with structurally similar nitromusks (moskene, musk xylene).
- Musk ambrette also caused positive patch tests without light exposure in some individuals.
Implications:
- Highlights the risk of musk ambrette in causing photoallergic contact dermatitis.
- Suggests potential for cross-reactivity with other nitromusks.
- Underscores the importance of identifying causative agents in photosensitive patients.
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