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Related Experiment Videos

[Chronic T-cell lymphoid leukemia with helper cell phenotype].

A G Merson, N M Gipsh, B A Shif

    Eksperimental'Naia Onkologiia
    |January 1, 1984
    PubMed
    Summary

    Tumor cells in T-cell chronic lymphocytic leukemia exhibit characteristics of T-helper lymphocytes. These malignant cells show limited reactivity to mitogens and allogeneic cells, with specific receptor modulation observed.

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    [The immune status of children with differing intensities of caries].

    Stomatologiia·1989

    Area of Science:

    • Immunology
    • Hematology
    • Oncology

    Context:

    • Characterizing the immunophenotype of malignant cells is crucial for understanding leukemia.
    • T-cell chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy with varying cell surface markers.

    Purpose:

    • To define the surface and cytochemical properties of T-cell CLL tumor cells.
    • To investigate the functional response of these malignant cells to various stimuli.

    Summary:

    • Tumor cells from a T-cell CLL patient displayed surface markers (E+, OKT3+, OKT4+, OKT8-, SIg-, Ia-) and cytochemical profiles consistent with T-helper lymphocytes.
    • These cells showed minimal Natural Killer (NK) and K-cell activity and weak responses to mitogens like phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM), as well as allogeneic cells.
    • Concanavalin A and PWM stimulation led to increased OKT3 and OKT4 receptor synthesis on malignant cells, while PHA reduced these receptors.

    Impact:

    • This detailed characterization aids in understanding T-cell CLL pathogenesis.
    • The findings contribute to the differential diagnosis and potential therapeutic strategies for T-cell malignancies.

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