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[Human leukocyte differentiation antigens].

A Bernard, L Boumsell

    Presse Medicale (Paris, France : 1983)
    |October 27, 1984
    PubMed
    Summary
    This summary is machine-generated.

    The First International Workshop on Human Leucocyte Differentiation Antigens standardized monoclonal antibodies against leucocytes, creating a unified nomenclature system. This classification aids in understanding leucocyte surface molecule organization and function.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Biochemistry

    Context:

    • Numerous monoclonal antibodies targeting leucocytes have been developed, leading to nomenclature confusion.
    • The proliferation of antibodies necessitated a standardized approach for clear identification and comparison.

    Purpose:

    • To establish a standardized nomenclature for human leucocyte differentiation antigens.
    • To facilitate clear communication and understanding among researchers studying leucocyte surface molecules.

    Summary:

    • The First International Workshop on Human Leucocyte Differentiation Antigens (Paris, 1982) successfully grouped monoclonal antibodies into differentiation classes based on shared molecular targets.
    • This led to the development of a unified nomenclature system, now adopted by the World Health Organization.

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  • The classification provides insights into the characteristics, organization, and function of leucocyte surface molecules.

    • Impact:

    • The established nomenclature system simplifies research and collaboration in leucocyte immunology.
    • It provides a framework for understanding the diversity and function of cell surface molecules.
    • Ongoing international workshops continue to refine this classification system.