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Topical v systemic agent treatment for papulopustular acne. A cost-effectiveness analysis
Archives of Dermatology
|December 1, 1984
Summary
Initial combination therapy for papulopustular acne (acne vulgaris) is cost-effective, reducing morbidity and costs despite a higher risk of side effects. Maintenance with topical agents is recommended post-clearance.
Area of Science:
- Dermatology
- Health Economics
- Pharmacoeconomics
Background:
- Papulopustular acne presents a significant morbidity burden.
- Treatment strategies vary, impacting costs, efficacy, and patient outcomes.
Purpose of the Study:
- To compare the cost-effectiveness of two initial treatment strategies for papulopustular acne.
- To evaluate the costs, risks, and benefits of topical therapy alone versus combination therapy (systemic antibiotics and topical agents).
Main Methods:
- Cost-effectiveness analysis was employed.
- Two strategies were compared: initial topical therapy alone versus initial combination therapy.
Main Results:
- Combination therapy resulted in fewer weeks of acne-related morbidity and lower overall dollar costs.
- Choosing topical therapy alone to minimize side effect risk incurs an additional $764 cost and 238 weeks of morbidity per patient to avoid one side effect instance.
Conclusions:
- Initial treatment of papulopustular acne with combined oral antibiotics and topical agents is cost-effective.
- Maintenance therapy with topical agents is advisable after achieving acne clearance.