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[Contact allergy to tromantadine].
Dermatosen in Beruf Und Umwelt. Occupation and Environment
|January 1, 1984
Summary
Allergic contact dermatitis can occur with topical tromantadine, a common herpes simplex virus treatment. Patch testing confirmed tromantadine allergy in 14 of 19 patients with dermatitis, indicating a need for caution.
Area of Science:
- Dermatology
- Virology
- Pharmacology
Context:
- Herpes simplex virus infections are common, yet effective topical treatments remain limited.
- Tromantadine hydrochloride (tromantadine) has been used as a topical antiviral agent since 1973.
- Reports of allergic contact dermatitis linked to tromantadine emerged in 1976.
Purpose:
- To investigate the incidence and clinical significance of allergic contact dermatitis caused by topical tromantadine.
- To evaluate patient sensitization to tromantadine and its gel base through patch testing.
Summary:
- Patch testing was conducted on 19 patients presenting with dermatitis after tromantadine application, revealing a 73.7% (14/19) rate of contact allergy to tromantadine.
- An additional 119 patients with various dermatoses underwent patch testing with tromantadine and its gel base.
- Two patients showed positive reactions to tromantadine, while two others reacted solely to the gel base; one of these also reacted to parabens.
Impact:
- This study highlights tromantadine as a potential allergen, necessitating careful consideration in clinical practice.
- Findings underscore the importance of patch testing for diagnosing contact dermatitis to topical medications.
- The results contribute to understanding adverse reactions associated with antiviral topical therapies.