[Use of amopen foaming tablets in treating chronic endometriosis in cows]

Pharmaceutic studies were carried out with a total of 89 cows affected with chronic endometritis, following up the biopharmacokinetic and therapeutic effect of amopen foaming tablets that contained amoxicillin trihydrate at the rate of 30,000 and 45,000 IU. Andreev's catheter was used to introduce the tablets into the uterus. It was found that the use of 600,000 IU amoxicillin developed therapeutic concentrations within the uterus up to the 48 h-72nd hour. Amoxicillin persisted in the blood serum up to the sixth hour. It was not eliminated by milk. The therapeutic effect with such cows (in which the causative organisms were susceptible to amoxicillin) to which the amopen tablets were introduced into the uterus (14 t. x 630,000 IU) three to four times at 48-hour intervals was shown to be 76 per cent. The use of 5 tablets of 45,000 IU at the 24th hour after the last insemination of cows that failed to conceive, exhibiting no symptoms of inflammation, raised the conception rate by 24.1 per cent.