Characteristics of lymphocyte and macrophage reactivity in otitis media with effusion

On the basis of our observations and previously published data, it is proposed that in at least certain forms of chronic otitis media with effusion there is a relative predominance of macrophage--monocyte cells which are actively immunosuppressive for the proliferative response to mitogens and specific antigens, as well as for the synthesis of specific immunoglobulins. Such immunological hypo-responsiveness may be related to the pathogenesis of chronic otitis media with such effusions.