[The nucleus of the cardiac myocyte in ventricular hypertrophy. Ultrastructural study]

This study reports the nuclear alterations during ventricular hypertrophy of human heart. The nuclear length is increased while its diameter remains normal. A large spectrum of morphological alterations was observed: increased foldings and convolutions of the membrane; irregular shape of the nuclei, some of them being dumbbell-shaped; intranuclear pseudo-inclusions; intranuclear tubules. These alterations are related to excessive synthesis of membrane during nuclear growth.