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Ontogenetic determinants of behavioral responses to morphine in rats
Drug and Alcohol Dependence
|February 1, 1980
Abstract:
Male Sprague-Dawley rats ranging in age from 20 to 110 days were injected with two doses of morphine sulphate, and examined for behavioral activation and catalepsy. Behavioral activation increased with age, while sensitivity to catalepsy declined. Ontogenetic and pharmacological responses suggest possible separate mediation of activation and catalepsy.