Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A defect in platelet aggregation in Bartter's syndrome.

J S Stoff, M Stemerman, M Steer

    The American Journal of Medicine
    |February 1, 1980
    PubMed
    Summary

    Patients with Bartter's syndrome exhibit a unique platelet aggregation defect, linked to altered prostaglandin metabolism and elevated cyclic adenosine 5'-monophosphate (AMP) levels. This finding sheds light on platelet dysfunction in this condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bacterial Community Modifies Host Genetics Effect on Early Childhood Caries.

    Journal of dental research·2023
    Same author

    Plaque Microbiome in Caries-Active and Caries-Free Teeth by Dentition.

    JDR clinical and translational research·2022
    Same author

    Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model.

    The British journal of surgery·2018
    Same author

    A qualitative exploration of stakeholder perceptions of the implementation of place-based working and its potential to reduce health inequality.

    Journal of public health (Oxford, England)·2018
    Same author

    Predictors of liver donation without kidney recovery in a cohort of expanded criteria donors: identifying opportunities to improve expanded criteria donor kidney utilization.

    Transplantation proceedings·2012
    Same author

    Association of marital status with access to renal transplantation.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010

    Area of Science:

    • Hematology
    • Nephrology
    • Biochemistry

    Background:

    • Bartter's syndrome is a rare kidney disorder characterized by electrolyte imbalances.
    • Platelet function and its relationship with prostaglandin metabolism in Bartter's syndrome remain incompletely understood.

    Observation:

    • Four subjects with Bartter's syndrome displayed impaired platelet aggregation in both primary and secondary phases, despite normal bleeding times.
    • This platelet abnormality worsened with sodium restriction and improved with prostaglandin synthesis inhibitors.

    Findings:

    • The observed platelet defect was specific to Bartter's syndrome, not seen in other hypokalemic patients or healthy controls.
    • Platelet-rich plasma from affected subjects showed elevated cyclic adenosine 5 omino-monophosphate (AMP) levels, correlating with disordered platelet function.

    Related Experiment Videos

  • Plasma from Bartter's syndrome patients induced both high cyclic AMP and aggregation defects in normal platelets, suggesting a plasma factor.

    • Implications:

    • These findings identify a novel platelet aggregation defect associated with Bartter's syndrome.
    • The results suggest a link between altered prostaglandin metabolism, elevated cyclic AMP, and impaired platelet function in this condition.
    • Further research may elucidate therapeutic strategies targeting platelet dysfunction in Bartter's syndrome.