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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Host-induced virus modification of murine hepatitis virus: changes in thermal stability
Intervirology
|January 1, 1980
Abstract:
Serial tissue culture passage of two cold-sensitive mutants of murine hepatitis virus altered the thermal stability of one mutant. This phenomenon occurred in only one of the continuous cell lines tested and was reversible by multiple passages in a cell line that does not alter thermal stability. The effect was cumulative with passage and was segregated from the cold-sensitive marker.
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