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Mild transmissible gastroenteritis in pigs suckling vaccinated sows
Journal of the American Veterinary Medical Association
|March 15, 1980
Summary
A low-virulence transmissible gastroenteritis (TGE) virus strain was isolated from vaccinated pigs. While TGEV caused diarrhea, it was not lethal in older suckling pigs, suggesting reduced virulence post-vaccination.
Area of Science:
- Veterinary Virology
- Swine Disease Research
Background:
- Transmissible gastroenteritis (TGE) is a significant swine disease.
- Vaccination with attenuated TGE virus aims to protect piglets.
- Understanding TGEV virulence is crucial for disease control.
Observation:
- A low-virulence TGE virus strain was isolated from pigs nursing vaccinated sows.
- Diarrhea occurred in suckling pigs around 14 days post-farrowing.
- Diarrhea resolved after sow vaccination ceased.
Findings:
- The isolated field strain and vaccine strain were infective and potentially lethal to 2-day-old pigs.
- Neither the field isolate nor the vaccine strain exhibited the high virulence of the Purdue strain.
- Low virulence was observed in pigs older than 2 days, suggesting age-dependent susceptibility.
Implications:
- The findings suggest that TGE vaccination may reduce virus virulence in field strains.
- Further research is needed to assess the impact of vaccination on TGEV transmission dynamics.
- Understanding virulence factors is essential for developing more effective TGE vaccines and control strategies.