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Progeny testing for bovine syndactyly.

J L Johnson, H W Leipold, G W Snider

Journal of the American Veterinary Medical Association

|March 15, 1980

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Genetic testing identified two Holstein-Friesian bulls heterozygous for syndactyly using superovulation and embryo transfer. The remaining bulls were confirmed homozygous normal, aiding in genetic disease management in cattle.

Area of Science:

Animal genetics
Veterinary medicine
Reproductive biology

Background:

Syndactyly is a congenital limb defect affecting cattle.
Accurate genetic diagnosis is crucial for herd management and breeding programs.

Purpose of the Study:

To determine the heterozygous status of four Holstein-Friesian bulls for syndactyly.
To differentiate between heterozygous and homozygous normal bulls for this genetic anomaly.

Main Methods:

Utilized syndactylous donors, superovulation, and embryo transfer techniques.
Fetal sexing and genetic analysis were performed via cesarean section.
Four Holstein-Friesian bulls were tested for syndactyly inheritance.

Main Results:

Related Experiment Videos

Two bulls sired syndactylous fetuses, confirming heterozygous status for syndactyly.
Two bulls sired eight normal fetuses each, indicating homozygous normal genotype.
Cesarean section facilitated direct examination of fetal phenotypes.

Conclusions:

Established a reliable method for identifying heterozygous syndactyly carriers in bulls.
Provided genetic data crucial for selective breeding and controlling syndactyly in Holstein-Friesian cattle.
Confirmed the utility of reproductive technologies in genetic disease diagnostics.