[Ultrastructural and functional changes in the synaptosomes of the rat brain on in vitro electrostimulation]

Electrostimulation of suspension of the rat brain synaptosomes causes Ca(2)+-dependent endogenous norepinephrine release and at the same time Ca(2)-dependent increase of the mediator content in the synaptosomes. The activity of cAMP declines under the same conditions. Electrostimulation does not alter the ultrastructure of the synaptosomes but raises the content of high electron density synaptosomes.