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Changes in plasma cyclic nucleotides levels during various acute physical stresses
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|February 1, 1980
Summary
Exercise increases plasma cyclic AMP (adenosine monophosphate) and cyclic GMP (guanosine monophosphate) in humans. Propranolol blocked cyclic AMP, while atropine blocked cyclic GMP, indicating distinct roles in sympathetic nerve activity.
Area of Science:
- Human physiology
- Autonomic nervous system function
- Biochemical signaling
Background:
- Sympathetic nerve activity influences various physiological processes.
- Cyclic nucleotides like cyclic AMP and cyclic GMP are key intracellular messengers.
- Understanding their role during stress is crucial for human health.
Purpose of the Study:
- To investigate the impact of sympathetic nerve-activating stresses on plasma cyclic AMP and cyclic GMP levels.
- To determine if these cyclic nucleotides can serve as biomarkers for specific autonomic functions during exercise.
Main Methods:
- Healthy volunteers underwent various stress tests, including exercise, tilting, and cold pressor.
- Plasma concentrations of cyclic AMP and cyclic GMP were measured.
- Pharmacological interventions (propranolol, atropine) were used to probe signaling pathways.
Main Results:
- Exercise significantly increased plasma cyclic AMP, an effect abolished by propranolol (a beta-adrenergic blocker).
- Exercise also slightly increased plasma cyclic GMP, an effect abolished by atropine (a cholinergic blocker).
- Tilting and cold pressor stress did not induce significant changes in these cyclic nucleotides.
Conclusions:
- Plasma cyclic AMP levels during exercise may reflect beta-adrenergic function.
- Plasma cyclic GMP levels during exercise may reflect cholinergic function.
- These cyclic nucleotides show potential as indices for specific autonomic functions during human exercise.