Cushing's disease with hyperprolactinaemia treated by transsphenoidal hypophysectomy

Area of Science:

• Endocrinology
• Neurosurgery

Background:

• Cushing's disease and hyperprolactinaemia are distinct endocrine disorders.
• Concurrent presentation of these conditions is rare.

Observation:

• A patient presented with co-existing Cushing's disease and hyperprolactinaemia.
• Endocrine testing revealed independent abnormalities characteristic of each condition.

Findings:

• Both hypercortisolism (Cushing's disease) and hyperprolactinaemia were suppressed independently.
• Transsphenoidal hypophysectomy resulted in apparent resolution of both endocrinopathies.

Implications:

• This case highlights the potential for successful surgical management of combined pituitary-related endocrine disorders.
• Transsphenoidal hypophysectomy may be an effective treatment for patients with concurrent Cushing's disease and hyperprolactinaemia.