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Related Experiment Videos

New transfusion program for an intensive care nursery.

J D Johnson, N C Malachowski, P Sunshine

    The Journal of Pediatrics
    |November 1, 1980
    PubMed
    Summary

    This study introduces a new neonatal intensive care nursery transfusion program using type O Rh0(D) negative packed red blood cells. The innovative method efficiently provides multiple transfusions to infants while maintaining safety and comparable infection rates.

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    Area of Science:

    • Neonatal Medicine
    • Transfusion Medicine
    • Pediatric Hematology

    Background:

    • Neonatal intensive care units (NICUs) require efficient blood transfusion strategies.
    • Optimizing the use of limited blood resources is crucial for infant care.
    • Previous transfusion protocols may have limitations in resource utilization and safety.

    Purpose of the Study:

    • To establish and evaluate a novel transfusion program for NICU infants.
    • To improve the utilization of O Rh0(D) negative packed red blood cells.
    • To assess the safety and efficacy of the new transfusion protocol.

    Main Methods:

    • Crossmatching multiple infants to single units of O Rh0(D) negative packed red blood cells.
    • Dividing donor units into quadpacks for multi-infant use.

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  • Allowing multiple entries into quadpacks within a 24-hour period.

    • Main Results:

    • Each donor unit supported transfusions for up to four infants over four days.
    • Cytomegalovirus (CMV) infection prevalence was 20% at 10 months, comparable to other studies.
    • No evidence of Hepatitis B (HB) transmission was found.
    • A low risk of allosensitization to red cell and lymphocyte antigens was observed.

    Conclusions:

    • The new transfusion program effectively maximizes the use of O Rh0(D) negative packed red blood cells in the NICU.
    • The protocol demonstrates a favorable safety profile regarding viral transmission and allosensitization.
    • This approach offers a viable strategy for resource optimization in neonatal transfusion practices.