Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Mitomycin C in advanced gallbladder carcinoma.

F von Eyben, C Hellekant, W Mattsson

Acta Radiologica. Oncology

|January 1, 1980

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Limited opportunity for nursing students to perform practical nursing skills during clinical placements: a Scandinavian cross-sectional study.

International journal of nursing studies advances·2026

Same author

Unspoken synergy: Team interdependence with radiographers in trauma alerts - An interview and observational study of trauma teams.

Radiography (London, England : 1995)·2025

Same author

On the edge of decision-making in trauma care: A focus group study on radiographers' experiences of interprofessional collaboration.

Radiography (London, England : 1995)·2023

Same author

Drivers of changing urban flood risk: A framework for action.

Journal of environmental management·2019

Same author

Neonatal intestinal colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae-a 5-year follow-up study.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018

Same author

An outbreak of mumps in Sweden, February-April 2004.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2017

Same journal

Neutron dosimetry with detectors of finite size. II. Experiments and calculations.

Acta radiologica. Oncology·1986

Same journal

Neutron dosimetry with detectors of finite size. I. Theory.

Acta radiologica. Oncology·1986

Same journal

Combined effects of ultrasound and ionizing radiation on lymphocyte chromosomes.

Acta radiologica. Oncology·1986

Same journal

Radiosensitizing effects of nicotinamide on a C3H mouse mammary adenocarcinoma. A study on per os drug administration.

Acta radiologica. Oncology·1986

Same journal

Radiobiologic response of CHO-KI cells treated with vitamin A.

Acta radiologica. Oncology·1986

Same journal

Cell size following irradiation in relation to cell cycle.

Acta radiologica. Oncology·1986

See all related articles

Mitomycin C treatment for advanced gallbladder carcinoma showed limited efficacy, with stationary disease in some patients but also progressive disease and treatment failures. Median survival was 4 months, with significant toxicities like thrombocytopenia observed.

Area of Science:

Oncology
Pharmacology

Background:

Advanced gallbladder carcinoma has a poor prognosis.
Chemotherapy options for advanced gallbladder cancer are limited.

Purpose of the Study:

To evaluate the efficacy and safety of mitomycin C in patients with advanced gallbladder carcinoma.

Main Methods:

Seven patients with advanced gallbladder carcinoma received intraarterial mitomycin C infusions.
Three patients received intravenous mitomycin C infusions.
Treatment response and survival were monitored.

Main Results:

Stationary disease was achieved in 4 patients, while 4 experienced progressive disease.
Median survival after mitomycin C treatment was 4 months.

Related Experiment Videos

Adverse events included irreversible thrombocytopenia in 2 patients and severe gastrointestinal bleeding in one.

Conclusions:

Mitomycin C demonstrated limited efficacy in advanced gallbladder carcinoma.
Significant toxicities necessitate careful patient selection and monitoring.