Related Experiment Videos
Elevated CSF cyclic AMP concentrations in patients with inflammatory diseases of cerebral and extracerebral origin
Insights
Cyclic 3'-5' adenosine monophosphate (c-AMP) is elevated in cerebrospinal fluid during meningitis and other febrile conditions. This suggests c-AMP may indicate brain metabolic disturbances.
Area of Science:
- Neuroscience
- Biochemistry
- Pediatrics
Background:
- Meningitis is a serious infection affecting the central nervous system.
- Cerebrospinal fluid (CSF) analysis is crucial for diagnosing neurological conditions.
- Cellular metabolic disturbances can occur in various brain-related illnesses.
Purpose of the Study:
- To investigate cyclic 3 -5 adenosine monophosphate (c-AMP) levels in CSF of children with suspected meningitis.
- To determine if c-AMP can serve as a biomarker for meningitis and other inflammatory brain conditions.
Main Methods:
- Measurement of c-AMP concentrations in CSF samples.
- Analysis of CSF from children with purulent meningitis, aseptic meningitis, and other febrile conditions.
- Comparison of c-AMP levels with routine CSF parameters and clinical outcomes.
Main Results:
- Markedly elevated c-AMP levels were observed in acute purulent and aseptic meningitis.
- Elevated c-AMP persisted in convalescent meningitis patients even after routine CSF parameters normalized.
- Non-cerebral febrile inflammatory conditions also showed elevated CSF c-AMP, despite normal routine CSF findings.
Conclusions:
- CSF c-AMP is a sensitive indicator of elevated cyclic adenosine monophosphate in meningitis.
- Elevated c-AMP may reflect transient cellular metabolic disturbances in the brain.
- c-AMP shows potential as a biomarker for neurological and inflammatory conditions affecting the brain.
Abstract:
Cyclic 3'-5' adenosine monophosphate (c-AMP) concentrations were measured in cerebrospinal fluid (CSF) from children admitted to the hospital because of suspected meningitis. c-AMP levels were found to be markedly elevated (P < 0.001) during the acute phase of most of the purulent meningitis patients, as well as in patients with acute aseptic meningitis. In convalescent patients after purulent meningitis mean c-AMP concentrations remained elevated (P < 0.01) beyond the normalization of the routine parameters in CSF. In addition, a variety of febrile inflammatory conditions of extracerebral origin produced elevations (P < 0.001) of c-AMP although CSF by routine criteria was normal. The results suggest that c-AMP might serve as a sensitive indicator of transient cellular metabolic disturbance in the brain.