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[Persistant pubertal gynecomastia. Biological study (author's transl)].

C Sultan, N Bressot, P Garandeau

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |December 8, 1980
    PubMed
    Summary

    Persistent pubertal gynecomastia in boys may stem from heightened mammary tissue sensitivity to estrogens, potentially linked to insufficient prenatal masculinization. This condition shows higher estrogen levels and a lower testosterone/estradiol ratio.

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    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Pediatric Endocrinology

    Context:

    • Persistent pubertal gynecomastia presents distinct characteristics compared to physiologic breast enlargement.
    • This study investigated hormonal and tissue-specific factors in 17 affected boys.

    Purpose:

    • To elucidate the underlying biological mechanisms of persistent pubertal gynecomastia.
    • To identify key hormonal imbalances and tissue sensitivities contributing to the condition.

    Summary:

    • Boys with persistent pubertal gynecomastia exhibited elevated plasma estrogens and urinary phenol steroids.
    • A decreased plasma testosterone/estradiol ratio and transient prolactin increase were observed.
    • Mammary tissue lacked detectable estrogen receptors, with aromatase activity similar to adipose tissue.

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    Impact:

    • Findings suggest that persistent pubertal gynecomastia may result from increased mammary tissue sensitivity to estrogens.
    • This hypersensitivity could be influenced by inadequate intrauterine masculinization of the mammary anlage.
    • Understanding these factors is crucial for diagnosing and managing persistent pubertal gynecomastia in adolescents.