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Updated: Jan 24, 2026
10:51
Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
4.6K
Summary
Male breast cancer is rare, with infiltrating duct carcinoma being most common. Axillary lymph node involvement significantly predicts a poor prognosis, despite other contributing factors.
Area of Science:
- Oncology
- Surgical Oncology
Background:
- Male breast cancer is a rare malignancy.
- Incidence is approximately 0.53% of all male cancers and 3.2% of all mammary cancers.
Purpose of the Study:
- To analyze the clinical characteristics, treatment, and outcomes of male breast cancer.
- To identify prognostic factors in male breast cancer.
Main Methods:
- Retrospective case series of 27 male breast cancer patients treated between 1966-1978.
- Analysis of presenting features, tumor histology, staging, treatment modalities, and survival data.
Main Results:
- Mean age was 52 years; commonest presentation was breast lump followed by skin ulceration.
- Infiltrating duct carcinoma (25 cases) was predominant; 2-year survival was poor, with only 4 patients surviving >5 years.
- Axillary lymph node involvement was the primary determinant of poor prognosis, with other factors including symptom duration, age, and skin involvement also noted.
Conclusions:
- Male breast cancer prognosis is significantly influenced by axillary lymph node status.
- Early detection and prompt treatment are crucial for improving outcomes in male breast cancer.
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