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Mammalian cell function mediating recombination of genetic elements.

P Upcroft, B Carter, C Kidson

    Nucleic Acids Research
    |December 11, 1980
    PubMed
    Summary
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    This study details Simian virus 40 (SV40) genome recombination mechanisms, including novel ways linear DNA segments join. Viral proteins are not essential for these genetic recombination events.

    Area of Science:

    • Molecular Biology
    • Virology
    • Genetics

    Background:

    • Simian virus 40 (SV40) is a well-studied model organism for DNA replication and recombination.
    • Previous research has identified various mechanisms for SV40 genome recombination, often involving specific DNA termini or viral proteins.

    Purpose of the Study:

    • To describe novel mechanisms of SV40 genome segment recombination.
    • To investigate the role of viral proteins in these recombination processes.
    • To characterize the nature of SV40 genome segments unable to produce viral proteins.

    Main Methods:

    • Analysis of SV40 genome segment joining.
    • Investigation of DNA termini structures (flush, cohesive, resected).
    • Assessment of viral protein involvement in recombination.

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    Main Results:

    • Demonstration of faithful joining of linear SV40 genome segments with flush termini.
    • Evidence for lack of viral protein involvement in recombination of segments with homologous overlapping termini.
    • Identification of cleaved SV40 genome segments as neutral genetic elements prior to recombination.

    Conclusions:

    • SV40 genome recombination can occur through multiple pathways, including those not requiring viral proteins.
    • Recombination functions appear to be host cell-mediated.
    • Cleaved SV40 genome segments function as passive genetic information until recombination occurs.