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Intracranial growth of pulmonary small cell carcinoma cells in nude athymic mice
Abstract:
Pulmonary small cell carcinoma of the lung cells were inoculated intracranially and subdermally in nude athymic mice (Balb/c strain). There was a 100% intracranial tumor incidence in response to 1/10th the cell dose required to produce subdermal tumors in immunosuppressed nude mice. Tumors did not grow in the brains of Balb/c normal (haired) mice.
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