[Taurine and the adenosine cyclic monophosphate levels in the heart]

The mechanism of the decrease in the heart of cAMP content under the effect of taurine was studied. It was shown on a preparation of cytoplasmic membranes isolated from the rat heart that under the effect of taurine (10(-6)--10(-3) M) the activity of phosphodiesterase and adenylate cyclase increases to the maximum by 2.4 and 1.4 times, respectively. Taurine weakens the activation of adenylate cyclase by adrenaline. The effect of taurine on adenylate cyclase activity diminishes under the action of phentolamine and obsidan and is practically not manifested in the simultaneous presence of both adrenoblocking agents. Taurine obviously changes the content of cAMP in the heart by altering the activity of adenylate cyclase and phosphodiesterase.