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Related Experiment Videos

Morphine antagonists and consummatory behaviors.

N L Ostrowski, N Rowland, T L Foley

    Pharmacology, Biochemistry, and Behavior
    |April 1, 1981
    PubMed
    Summary
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    Opiate antagonists like naloxone reduce drinking and eating behaviors, indicating endorphins

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Pharmacology

    Background:

    • Opiate antagonists are known to modulate various physiological processes.
    • The role of endorphins in regulating ingestive behaviors requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of opiate antagonists on drinking and eating behaviors.
    • To determine the central nervous system involvement and stereospecificity of these effects.

    Main Methods:

    • Eight experiments were conducted using opiate antagonists including naloxone, nalorphine, and WIN 44,441 isomers.
    • Drinking was induced by osmotic, volemic, hormonal challenges, and eating by glucoprivation or tail-pressure stimulation.

    Main Results:

    Related Experiment Videos

  • Naloxone, nalorphine, and the active WIN 44,441 isomer significantly reduced drinking.
  • Central nervous system-acting antagonists demonstrated stereospecificity, unlike peripherally acting analogs.
  • Naloxone suppressed eating induced by glucoprivation but not tail-pressure stimulation.

    • Conclusions:

    • Endorphins play a significant role in the central nervous system's organization of ingestive behavior.
    • Opiate antagonists exhibit stereospecific effects within the central nervous system.
    • These findings contribute to understanding the neurobiological basis of appetite regulation.