Cholecystokinin and satiety in pigs

Area of Science:

• Gastroenterology
• Neuroscience
• Animal Science

Background:

• The hormone cholecystokinin (CCK) is known to influence feeding behavior.
• Understanding the mechanisms of satiety is crucial for managing appetite and metabolic health.

Purpose of the Study:

• To investigate the role of cholecystokinin (CCK) in satiety.
• To determine if CCK, caerulein, and CCK-octapeptide induce satiety in pigs.
• To explore the involvement of CCK in preabsorptive satiety.

Main Methods:

• Twenty-three pigs were fitted with various catheters (intraperitoneal, intrajugular, intraportal, intraduodenal).
• Pigs were administered cholecystokinin (CCK), caerulein, CCK-octapeptide, sodium oleate, or protein hydrolysate.
• Pelleted feed intake was measured after administration of test substances or control injections.

Main Results:

• All tested substances, including CCK and its analogues, dose-dependently suppressed feed intake in pigs.
• Intraportal administration of CCK resulted in a greater feeding depression compared to other routes.
• CCK, caerulein, and CCK-octapeptide did not form conditioned taste aversions.
• Satiety effects of sodium oleate and protein hydrolysate were reduced by tetracaine.

Conclusions:

• The findings support the hypothesis that CCK plays a role in rapid, preabsorptive satiety.
• CCK and related peptides are potent appetite suppressants in pigs.
• The study highlights the physiological mechanisms underlying CCK-mediated satiety.