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Human glomerulonephritis and persistent non-polio enterovirus infection
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
|January 1, 1980
Summary
Persistent non-polio enterovirus (NPEV) excretion in urine and stools is linked to active glomerulonephritis (GN). This study found a significant association between ongoing viral shedding and the occurrence of GN in humans.
Area of Science:
- Virology
- Nephrology
- Immunology
Background:
- Non-polio enteroviruses (NPEVs) are implicated in various human diseases.
- The role of persistent viral infections in the pathogenesis of glomerulonephritis (GN) remains incompletely understood.
Purpose of the Study:
- To investigate the association between NPEV excretion and the occurrence of active GN.
- To determine if persistent NPEV shedding is linked to the development or activity of GN.
Main Methods:
- Prospective study involving four groups: exposed controls, patients with proven GN, proven non-GN, and probable non-GN.
- Detection of NPEV in urine and stool samples using cell cultures.
- Follow-up studies to assess persistent viral excretion over 3-12 months.
Main Results:
- NPEV excretion was significantly higher in patients with proven GN (14% urine, 33% stool) compared to controls (0% urine, 5% stool).
- Viruria, indicative of viraemia, was associated with proven GN (p<0.05).
- Persistent NPEV excretion was confirmed in 73% of GN patients versus 0% in non-GN groups (p<0.001).
Conclusions:
- A significant relationship exists between persistent NPEV excretion and active GN in humans.
- Persistent viral infections, potentially via immune complex mechanisms involving viral antigens, may cause certain types of GN.