Cortically elicited spike-wave after discharges in thalamic neurons

Self-sustained, 3-4/sec spike-wave ADs were elicited in lateralis intermedius-lateralis posterior thalamic bursting neurons following incremental responses elicited by 10/sec shock-trains applied to the anterior suprasylvian cortex. The pattern of cortically elicited thalamic spike-wave complexes, with brief depolarizing components and a long-lasting hyperpolarizing wave, resembles that of previously described spike-wave seizures elicited in cortical interneurons following specific thalamo-cortical augmenting responses.