[Role of biological membrane lipid component in hormone reception and adenylate cyclase system function]

The paper deals with a review of experimental data evidencing for an important role of phospholipids in regulation of the activity of the adenylate cyclase system sensitive to hormonal effects. These compounds play a structural role and evidently keep the receptor-enzymic complex in the state sensitive to the hormone effect. Phospholipids form a complex with the receptor subunit of adenylate cyclase or determine its microenvironment and take part in hormonal binding. Lipid components are transmitters or modulators of physico-chemical signals formed during hormone-receptor interaction. A supposition is made that phosphatidyl ethanolamine, phosphatidyl serine and probably phosphatidyl inositol interact with the catalytic subunit of adenylate cyclase and determine its activity. Supposing that several hormonal receptors are associated with adenylate cyclase only, it may be admitted that each receptor is linked with it through separate fractions of phospholipids.